Information on Ultram

Ultram is a non-opiod anagesic used in the treatment and prevention of pain.

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Ultram acts on the central nervous system and unlike codeine, it is a totally synthetic analgesic compound. Although its mode of action is not completely understood, from animal tests, at least two complementary mechanisms appear applicable: the binding of parent compound to opioid receptors and weak inhibition of reuptake of norepinephrine and serotonin by nerves located within the central nervous system. These mechanisms may contribute independently to the overall analgesic profile of Ultram. Analgesia in humans begins approximately within one hour after administration and reaches a peak in approximately two to three hours.

How to take Ultram:

For the treatment of pain, Ultram 50 mg to 100 mg can be administered as needed for relief every four to six hours, not to exceed 400 mg per day. For moderate pain, Ultram 50 mg may be adequate as the initial dose, and for more severe pain, ULTRAM 100 mg is usually more effective as the initial dose.

How effective is Ultram?

Ultram has been given in single oral doses of 50, 75, and 100mg to patients with pain following surgical procedures and pain following oral surgery. In single doses of pain following oral surgery, pain relief was seen in some patients at doses of 50 mg and 75 mg. A dose of 100 mg of Ultram tended to provide analgesia superior to codeine sulfate 60 mg.

How long should can I take Ultram?

Ultram is a short-term drug for the treatment of pain relief.

Dependence:

Ultram has a potential to cause physical dependence of the morphone-type class. The drug has been associated with craving, drug-seeking behavior and tolerance development. Cases of abuse and dependence on Ultram have been reported.

Ultram should not be used in opioid-dependent patients. ULTRAM can reinitiate physical dependence in patients that have been previously dependent or chronically using other opioids. In patients with a tendency to drug abuse, a history of drug dependence, or are chronically using opioids, treatment with Ultram is not recommended.

Seizure Risk:

Seizures have been reported in patients receiving ULTRAM within the recommended dosage range. Concomitant use of ULTRAM increases the seizure risk in patients taking:

Selective serotonin reuptake inhibitors (SSRI antidepressants or anoretics -phentermine),

Tricyclic antidepressants and other tricyclic compounds (e.g., cyclobenzaprine, promethazine, etc.)

Opioids.

MAO inhibitors

Neuroleptics

Any drugs that reduce the seizure threshold

Epilepsy

Side Effects:

Ultram may impair mental or physical abilities required for the performance of potentially hazardous tasks such as driving a car or operating machinery.

Ultram should not be taken with alcohol containing beverages.

Ultram should be used with caution when taking medications such hypnotics or other opiate containing analgesics.

Contra-indications:

Ultram should not be used in pregnant women or nursing mothers, safe use in pregnancy has not been established.

Chronic use during pregnancy may lead to physical dependence and post-pregnancy withdrawal symptoms in the newborn.

Ultram has been shown to cross the placenta. Nonetheless, the effect of Ultram, if any, on the later growth, development, and functional maturation of the child is unknown.

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